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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-5-12
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pubmed:abstractText |
Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor. One of many down-stream MYCN targets is miR-184, which is either directly or indirectly repressed by this transcription factor, possibly due to its pro-apoptotic effects when ectopically over-expressed in neuroblastoma cells. The purpose of this study was to elucidate the molecular mechanism by which miR-184 conveys pro-apoptotic effects.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20409325-Apoptosis,
pubmed-meshheading:20409325-Blotting, Western,
pubmed-meshheading:20409325-Cell Line, Tumor,
pubmed-meshheading:20409325-Gene Expression,
pubmed-meshheading:20409325-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20409325-Humans,
pubmed-meshheading:20409325-MicroRNAs,
pubmed-meshheading:20409325-Neuroblastoma,
pubmed-meshheading:20409325-Nuclear Proteins,
pubmed-meshheading:20409325-Oncogene Proteins,
pubmed-meshheading:20409325-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20409325-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20409325-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2.
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pubmed:affiliation |
Department of Cancer Genetics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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