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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-7-13
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pubmed:abstractText |
Receptor-mediated endocytosis is a critical cellular mechanism for the uptake of lipoprotein cholesterol in the liver. Because Niemann-Pick C1 (NPC1) protein is a key component for the intracellular distribution of cholesterol originating from lipoprotein endocytosis, it may play an important role in controlling biliary cholesterol secretion and gallstone formation induced by a lithogenic diet.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol 7-alpha-Hydroxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Cholic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl CoA Reductases,
http://linkedlifedata.com/resource/pubmed/chemical/Npc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Npc2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Srebf2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol Regulatory Element Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/cytochrome P450 7A1, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1478-3231
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
887-97
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pubmed:meshHeading |
pubmed-meshheading:20408952-ATP-Binding Cassette Transporters,
pubmed-meshheading:20408952-Animals,
pubmed-meshheading:20408952-Bile,
pubmed-meshheading:20408952-Biological Transport,
pubmed-meshheading:20408952-Cholesterol, Dietary,
pubmed-meshheading:20408952-Cholesterol 7-alpha-Hydroxylase,
pubmed-meshheading:20408952-Cholic Acid,
pubmed-meshheading:20408952-Disease Models, Animal,
pubmed-meshheading:20408952-Gallstones,
pubmed-meshheading:20408952-Gene Expression Regulation,
pubmed-meshheading:20408952-Hydroxymethylglutaryl CoA Reductases,
pubmed-meshheading:20408952-Liver,
pubmed-meshheading:20408952-Male,
pubmed-meshheading:20408952-Mice,
pubmed-meshheading:20408952-Mice, Inbred BALB C,
pubmed-meshheading:20408952-Mice, Knockout,
pubmed-meshheading:20408952-Proteins,
pubmed-meshheading:20408952-RNA, Messenger,
pubmed-meshheading:20408952-Receptors, LDL,
pubmed-meshheading:20408952-Sterol Regulatory Element Binding Protein 2,
pubmed-meshheading:20408952-Vesicular Transport Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice.
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pubmed:affiliation |
Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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