Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-7-19
pubmed:abstractText
Age is the most important independent risk factor for stroke; however aging animals are rarely used in stroke studies. Previous work demonstrated that young male mice had more edema formation after an induced stroke than aging animals. An important contributor to cerebral edema formation is the Na-K-Cl cotransporter (NKCC). We examined the expression of NKCC in young (10-12 weeks) and aging (15-16 months) C57BL6 male mice after middle cerebral artery occlusion (MCAO) and investigated the effect of pharmacological inhibition of NKCC with Bumetanide on cerebral edema formation. Both immunofluorescent staining and Western blotting analysis showed that NKCC expression was significantly higher in the ischemic penumbra of young compared to aging mice after stroke. Edema formation was significantly more robust in young mice and was reduced with Bumetanide. Bumetanide had no effect on cerebral edema in aging mice after MCAO. This suggests that NKCC expression and edema formation are age dependent after ischemic stroke.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-10854255, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-11488540, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-11489443, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-11792363, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-12535773, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-1334094, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-15356425, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-15678112, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-15689952, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-15772080, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-15845211, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-16460584, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-16567697, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-17014830, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-17662011, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-17906823, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-17942640, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-17965526, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-18212524, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-18648381, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-18849345, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-19223913, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-19381858, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-8790807, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-9252456, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-9315452, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-9472888, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-9648855, http://linkedlifedata.com/resource/pubmed/commentcorrection/20406636-9672238
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1090-2430
pubmed:author
pubmed:copyrightInfo
(c) 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
224
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
356-61
pubmed:dateRevised
2011-8-3
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Expression of Na-K-Cl cotransporter and edema formation are age dependent after ischemic stroke.
pubmed:affiliation
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural