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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-5-20
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pubmed:abstractText |
Cell responses to environmental stimuli are usually organized as relatively separate responsive gene modules at the molecular level. Identification of responsive gene modules rather than individual differentially expressed (DE) genes will provide important information about the underlying molecular mechanisms. Most of current methods formulate module identification as an optimization problem: find the active sub-networks in the genome-wide gene network by maximizing the objective function considering the gene differential expression and/or the gene-gene co-expression information. Here we presented a new formulation of this task: a group of closely-connected and co-expressed DE genes in the gene network are regarded as the signatures of the underlying responsive gene modules; the modules can be identified by finding the signatures and then recovering the "missing parts" by adding the intermediate genes that connect the DE genes in the gene network.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1752-0509
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20406493-Humans,
pubmed-meshheading:20406493-Inflammation,
pubmed-meshheading:20406493-Umbilical Veins,
pubmed-meshheading:20406493-Time Factors,
pubmed-meshheading:20406493-Endothelium, Vascular,
pubmed-meshheading:20406493-Models, Biological,
pubmed-meshheading:20406493-Neovascularization, Pathologic,
pubmed-meshheading:20406493-Models, Genetic,
pubmed-meshheading:20406493-Gene Expression Regulation,
pubmed-meshheading:20406493-Signal Transduction,
pubmed-meshheading:20406493-Multigene Family
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