| pubmed-article:20406300 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C0029431 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C1414039 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C2245693 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:20406300 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20406300 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20406300 | pubmed:dateCreated | 2010-8-12 | lld:pubmed |
| pubmed-article:20406300 | pubmed:abstractText | Selective Alzheimer disease indicator-1 (seladin-1) is a broadly expressed oxidoreductase and is related to Alzheimer disease, cholesterol metabolism and carcinogenesis. The effect of lipopolysaccharide (LPS) on the expression of seladin-1 was examined using RAW 264.7 macrophage-like cells and murine peritoneal macrophages. Lipopolysaccharide induced the expression of seladin-1 protein and messenger RNA in those macrophages. The seladin-1 expression was also augmented by a series of Toll-like receptor ligands. The LPS augmented the expression of seladin-1 via reactive oxygen species generation and p38 activation. Seladin-1 inhibited LPS-induced activation of p38 but not nuclear factor-kappaB and inhibited the production of tumour necrosis factor-alpha in response to LPS. Moreover, seladin-1 inhibited LPS-induced osteoclast formation and enhanced LPS-induced alkaline phosphatase activity. Therefore, it was suggested that seladin-1 might be an LPS-responsible gene product and regulate the LPS-induced inflammatory response negatively. | lld:pubmed |
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| pubmed-article:20406300 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20406300 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20406300 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20406300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20406300 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20406300 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20406300 | pubmed:issn | 1365-2567 | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:KomatsuTakayu... | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:YokochiTakash... | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:YoshidaTomoak... | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:KoideNaokiN | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:NaikiYoshikaz... | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:TumurkhuuGant... | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:DagvadorjJarg... | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:KhudaImtiaz... | lld:pubmed |
| pubmed-article:20406300 | pubmed:author | pubmed-author:NomanAbu S... | lld:pubmed |
| pubmed-article:20406300 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20406300 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:20406300 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20406300 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20406300 | pubmed:pagination | 59-66 | lld:pubmed |
| pubmed-article:20406300 | pubmed:dateRevised | 2011-9-13 | lld:pubmed |
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| pubmed-article:20406300 | pubmed:meshHeading | pubmed-meshheading:20406300... | lld:pubmed |
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| pubmed-article:20406300 | pubmed:meshHeading | pubmed-meshheading:20406300... | lld:pubmed |
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| pubmed-article:20406300 | pubmed:meshHeading | pubmed-meshheading:20406300... | lld:pubmed |
| pubmed-article:20406300 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20406300 | pubmed:articleTitle | Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. | lld:pubmed |
| pubmed-article:20406300 | pubmed:affiliation | Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. | lld:pubmed |
| pubmed-article:20406300 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20406300 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:74754 | entrezgene:pubmed | pubmed-article:20406300 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20406300 | lld:entrezgene |
