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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-8-12
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pubmed:abstractText |
Selective Alzheimer disease indicator-1 (seladin-1) is a broadly expressed oxidoreductase and is related to Alzheimer disease, cholesterol metabolism and carcinogenesis. The effect of lipopolysaccharide (LPS) on the expression of seladin-1 was examined using RAW 264.7 macrophage-like cells and murine peritoneal macrophages. Lipopolysaccharide induced the expression of seladin-1 protein and messenger RNA in those macrophages. The seladin-1 expression was also augmented by a series of Toll-like receptor ligands. The LPS augmented the expression of seladin-1 via reactive oxygen species generation and p38 activation. Seladin-1 inhibited LPS-induced activation of p38 but not nuclear factor-kappaB and inhibited the production of tumour necrosis factor-alpha in response to LPS. Moreover, seladin-1 inhibited LPS-induced osteoclast formation and enhanced LPS-induced alkaline phosphatase activity. Therefore, it was suggested that seladin-1 might be an LPS-responsible gene product and regulate the LPS-induced inflammatory response negatively.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-10559880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-11007892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-11009421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-11163183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-11519011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-15577914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-15864310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-15928677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-15950447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-15954227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-17063184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-17214836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-17538624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-17597583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-17984220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-18029230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-18339707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-18768664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-19220841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-6530697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-7828854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-8709748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-9294124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-9450875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-9826711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20406300-9990098
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1365-2567
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-66
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pubmed:dateRevised |
2011-9-13
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pubmed:meshHeading |
pubmed-meshheading:20406300-Animals,
pubmed-meshheading:20406300-Cell Line,
pubmed-meshheading:20406300-Lipopolysaccharides,
pubmed-meshheading:20406300-Macrophages,
pubmed-meshheading:20406300-Macrophages, Peritoneal,
pubmed-meshheading:20406300-Mice,
pubmed-meshheading:20406300-Nerve Tissue Proteins,
pubmed-meshheading:20406300-Osteoclasts,
pubmed-meshheading:20406300-Oxidoreductases Acting on CH-CH Group Donors,
pubmed-meshheading:20406300-Polymerase Chain Reaction,
pubmed-meshheading:20406300-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS.
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pubmed:affiliation |
Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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