Linked Life Data

20405893

Source:http://linkedlifedata.com/resource/pubmed/id/20405893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-5-14
pubmed:abstractText
In the production plant of an antibiotic substance, a new fluidized-bed drier has been installed. For online process control of the drying progress and determination of the ideal drying end point, a continuous near-infrared spectroscopic (NIRS) measuring setup was implemented to rapidly and simultaneously gain all essential product information. A bypass system outside the drier combined with a robust process probe proved to provide the best sampling system geometry. The spectrometer was equipped with an additional laboratory probe for complementary offline analysis. Multivariate calibrations for product assay, water content, and residual solvent were calculated, optimized, and compared for the two probes. The final root-mean-square error of cross validation (RMSECV) for the process probe could be reduced to 0.81% for the product assay, 0.25% for water, and 0.06% for acetone. The laboratory-probe prediction values show good agreement with reference data during the testing period. The calibrations of the process probe were checked by comparing its predictions to those of the validated laboratory probe. The monitoring system could be automated to a large extent, and product quality could be improved considerably. The established technology is of high importance for the pharmaceutical industry carrying out high-throughput routine analysis because of its advantages in terms of of time and cost reductions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1520-6882
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4209-15
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Online process control of a pharmaceutical intermediate in a fluidized-bed drier environment using near-infrared spectroscopy.
pubmed:affiliation
Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University, Innrain 52a, 6020 Innsbruck, Austria.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't