rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2010-4-21
|
pubmed:abstractText |
Treatment is initiated when the McDonald criteria for relapsing-remitting multiple sclerosis (RRMS) are fulfilled. High-risk patients with clinically isolated syndrome are followed using magnetic resonance imaging for one year after the first imaging. Interferon-beta or glatiramer acetate are the first-line immunomodulating drugs (IMD) for RRMS. MxA protein is measured 12 and 24 months after initiation of Interferon-beta to evaluate possible development of neutralizing antibodies. If MxA protein may not be detected repeatedly interferon-beta treatment is discontinued. If the disease is active in spite of treatment with first-line IMD, natalizumab may be considered as a second-line therapy. IMD is stopped when the transition to secondary progressive phase has occurred (or upon transition to secondary progressive phase).
|
pubmed:language |
fin
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0012-7183
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
126
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
199-200
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:20405605-Disease Progression,
pubmed-meshheading:20405605-GTP-Binding Proteins,
pubmed-meshheading:20405605-Humans,
pubmed-meshheading:20405605-Immunosuppressive Agents,
pubmed-meshheading:20405605-Interferon Type I,
pubmed-meshheading:20405605-Magnetic Resonance Imaging,
pubmed-meshheading:20405605-Multiple Sclerosis,
pubmed-meshheading:20405605-Multiple Sclerosis, Relapsing-Remitting,
pubmed-meshheading:20405605-Peptides,
pubmed-meshheading:20405605-Recombinant Proteins,
pubmed-meshheading:20405605-Treatment Outcome
|
pubmed:year |
2010
|
pubmed:articleTitle |
[Update on current care guidelines: diagnostics, treatment and rehabilitation of multiple sclerosis].
|
pubmed:publicationType |
Journal Article,
English Abstract,
Practice Guideline
|