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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-20
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pubmed:abstractText |
The mechanisms of hypertrophic scar formation are not fully understood. We previously screened the differentially expressed genes of human hypertrophic scar tissue and identified P311 gene as upregulated. As the activities of P311 in human fibroblast function are unknown, we examined the distribution of it and the effects of forced expression or silencing of expression of P311. P311 expression was detected in fibroblast-like cells from the hypertrophic scar of burn injury patients but not in peripheral blood mononuclear cells, bone marrow mesenchymal stem cells, epidermal cells or normal skin dermal cells. Transfection of fibroblasts with P311 gene stimulated the expression of alpha-smooth muscle actin (alpha-SMA), TGF-beta1 and alpha1(I) collagen (COL1A1), and enhanced the contraction of fibroblast populated collagen lattices (FPCL). In contrast, interference of fibroblast P311 gene expression decreased the TGF-beta1 mRNA expression and reduced the contraction of fibroblasts in FPCL. These results suggest that P311 may be involved in the pathogenesis of hypertrophic scar via induction of a myofibroblastic phenotype and of functions such as TGF-beta1 expression. P311 could be a novel target for the control of hypertrophic scar development.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-10471461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-10491047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-10660586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-12417574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-12813346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-14758226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-15365369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-15485502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-15625461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-16394352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-17671518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-18052725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-18161745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-18284397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-18354295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-18401422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-18616608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-18952381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-19285964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-19508304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-8106541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-8314838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-8537427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20404911-9082989
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ACTA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/C5orf13 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/collagen type I, alpha 1 chain
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e9995
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pubmed:dateRevised |
2011-7-15
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pubmed:meshHeading |
pubmed-meshheading:20404911-Actins,
pubmed-meshheading:20404911-Burns,
pubmed-meshheading:20404911-Cells, Cultured,
pubmed-meshheading:20404911-Cicatrix, Hypertrophic,
pubmed-meshheading:20404911-Collagen Type I,
pubmed-meshheading:20404911-Fibroblasts,
pubmed-meshheading:20404911-Gene Expression Regulation,
pubmed-meshheading:20404911-Humans,
pubmed-meshheading:20404911-Nerve Tissue Proteins,
pubmed-meshheading:20404911-Oncogene Proteins,
pubmed-meshheading:20404911-RNA, Messenger,
pubmed-meshheading:20404911-Transforming Growth Factor beta1
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pubmed:year |
2010
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pubmed:articleTitle |
Investigating the role of P311 in the hypertrophic scar.
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pubmed:affiliation |
State Key Laboratory for Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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