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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-5-31
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pubmed:abstractText |
Cohesin proteins help maintain the physical associations between sister chromatids that arise in S-phase and are removed in anaphase. Recent studies found that cohesins also localize to the centrosomes, the organelles that organize the mitotic bipolar spindle. We find that the cohesin protein Rad21 localizes to centrosomes in a manner that is dependent upon known regulators of sister chromatid cohesion as well as regulators of centrosome function. These data suggest that Rad21 functions at the centrosome and that the regulators of Rad21 coordinate the centrosome and chromosomal functions of cohesin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RAD21 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase,
http://linkedlifedata.com/resource/pubmed/chemical/cohesins,
http://linkedlifedata.com/resource/pubmed/chemical/polo-like kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/separase
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1551-4005
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1759-63
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:20404544-Anaphase,
pubmed-meshheading:20404544-Cell Cycle Proteins,
pubmed-meshheading:20404544-Centrosome,
pubmed-meshheading:20404544-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:20404544-Chromosome Segregation,
pubmed-meshheading:20404544-Endopeptidases,
pubmed-meshheading:20404544-HeLa Cells,
pubmed-meshheading:20404544-Humans,
pubmed-meshheading:20404544-Mitosis,
pubmed-meshheading:20404544-Nuclear Proteins,
pubmed-meshheading:20404544-Phosphoproteins,
pubmed-meshheading:20404544-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20404544-Proto-Oncogene Proteins,
pubmed-meshheading:20404544-RNA, Small Interfering,
pubmed-meshheading:20404544-RNA Interference
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pubmed:year |
2010
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pubmed:articleTitle |
Determinants of Rad21 localization at the centrosome in human cells.
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pubmed:affiliation |
Department of Genetics, Cell Biology & Development, University of Minnesota Medical School, Minneapolis, MN, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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