Linked Life Data

20403419

Source:http://linkedlifedata.com/resource/pubmed/id/20403419

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-9-27
pubmed:abstractText
In physiological conditions intracellular radical formation is mostly due to mitochondrial activity. This is in contrast to clinical and pathophysiological situations, where the oxidant formation is additionally driven by xenobiotics and inflammation. Oxidative damage accumulation in macromolecules especially in proteins has been considered as a cause of cellular damage and pathology impairing the clinical outcome of patients. However, up to now strategies to measure oxidative stress in clinical settings are limited. A lot of parameters and techniques are available for the determination of oxidized proteins in biological systems. Unfortunately, most of them are no reliable markers in clinical settings due to their unknown clinical relevance or the lack in clinical feasibility. Major problems are the sample availability, sample stability and cost-, time- and man-power intensive methods. The present review focuses on the measurement of protein oxidation products from a chemical, biological, and medical point of view.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1873-6815
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
733-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Biomarkers of protein oxidation from a chemical, biological and medical point of view.
pubmed:affiliation
Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany.
pubmed:publicationType
Journal Article, Review