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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2010-6-7
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pubmed:abstractText |
We previously characterized nucleoredoxin (NRX) as a negative regulator of the Wnt signaling pathway through Dishevelled (Dvl). We perform a comprehensive search for other NRX-interacting proteins and identify Flightless-I (Fli-I) as a novel NRX-binding partner. Fli-I binds to NRX and other related proteins, such as Rod-derived cone viability factor (RdCVF), whereas Dvl binds only to NRX. Endogenous NRX and Fli-I in vivo interactions are confirmed. Both NRX and RdCVF link Fli-I with myeloid differentiation primary response gene (88) (MyD88), an important adaptor protein for innate immune response. NRX and RdCVF also potentiate the negative effect of Fli-I upon lipopolysaccharide-induced activation of NF-kappaB through the Toll-like receptor 4/MyD88 pathway. Embryonic fibroblasts derived from NRX gene-targeted mice show aberrant NF-kappaB activation upon lipopolysaccharide stimulation. These results suggest that the NRX subfamily of proteins forms a link between MyD88 and Fli-I to mediate negative regulation of the Toll-like receptor 4/MyD88 pathway.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-10092519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-11171324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-11971982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-12150927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-12679023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-14602444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-14966289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-15220920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-15272023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-15829498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-15952741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-16410796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-16424162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-16604061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-17081971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-17115886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-17457343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-17567240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-18045904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-18406369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-18411310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-18691226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-18981228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-19720835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-2113574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-2499511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-8248259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-9119370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-9391086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20400501-9660869
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fli1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-fli-1,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/nucleoredoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1083-351X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
285
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18586-93
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pubmed:dateRevised |
2011-7-29
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pubmed:meshHeading |
pubmed-meshheading:20400501-Animals,
pubmed-meshheading:20400501-COS Cells,
pubmed-meshheading:20400501-Cercopithecus aethiops,
pubmed-meshheading:20400501-Fibroblasts,
pubmed-meshheading:20400501-Gene Expression Regulation,
pubmed-meshheading:20400501-Humans,
pubmed-meshheading:20400501-Immunity, Innate,
pubmed-meshheading:20400501-Lipopolysaccharides,
pubmed-meshheading:20400501-Mice,
pubmed-meshheading:20400501-Mice, Transgenic,
pubmed-meshheading:20400501-NF-kappa B,
pubmed-meshheading:20400501-NIH 3T3 Cells,
pubmed-meshheading:20400501-Nuclear Proteins,
pubmed-meshheading:20400501-Oxidoreductases,
pubmed-meshheading:20400501-Protein Binding,
pubmed-meshheading:20400501-Proto-Oncogene Protein c-fli-1,
pubmed-meshheading:20400501-Signal Transduction,
pubmed-meshheading:20400501-Toll-Like Receptor 4
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pubmed:year |
2010
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pubmed:articleTitle |
Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88).
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pubmed:affiliation |
Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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