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rdf:type |
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lifeskim:mentions |
umls-concept:C0005953,
umls-concept:C0007634,
umls-concept:C0012854,
umls-concept:C0026986,
umls-concept:C0030705,
umls-concept:C0085669,
umls-concept:C0178537,
umls-concept:C0443199,
umls-concept:C0936012,
umls-concept:C1332710,
umls-concept:C1511790,
umls-concept:C1513354,
umls-concept:C1519316,
umls-concept:C1521991,
umls-concept:C1655731,
umls-concept:C1707418
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pubmed:issue |
8
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pubmed:dateCreated |
2010-7-14
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pubmed:abstractText |
Recently, the "epigenetic molecular clock hypothesis" linked increasing DNA methylation in a distinct CpG island in the cardiac-specific homeobox gene (CSX) gene to relative mitotic cell age. To determine mitotic cell age in hematopoietic cells of myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) patients, we assessed differential CSX methylation patterns in these diseases vs age-adjusted healthy controls.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1873-2399
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pubmed:author |
pubmed-author:BaldusClaudia DCD,
pubmed-author:BenlasferOuidadO,
pubmed-author:HofmannWolf-KarstenWK,
pubmed-author:HopferOlafO,
pubmed-author:JohnThiloT,
pubmed-author:KmetschAnkeA,
pubmed-author:MossnerMaximilianM,
pubmed-author:NeumannUweU,
pubmed-author:NowakDanielD,
pubmed-author:PerkaCarstenC,
pubmed-author:ThielEckhardE
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pubmed:copyrightInfo |
2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
661-5
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pubmed:meshHeading |
pubmed-meshheading:20399247-Antigens, CD34,
pubmed-meshheading:20399247-Bone Marrow Cells,
pubmed-meshheading:20399247-Cell Aging,
pubmed-meshheading:20399247-CpG Islands,
pubmed-meshheading:20399247-DNA, Neoplasm,
pubmed-meshheading:20399247-DNA Methylation,
pubmed-meshheading:20399247-Homeodomain Proteins,
pubmed-meshheading:20399247-Humans,
pubmed-meshheading:20399247-Leukemia, Myeloid, Acute,
pubmed-meshheading:20399247-Mitosis,
pubmed-meshheading:20399247-Myelodysplastic Syndromes,
pubmed-meshheading:20399247-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:20399247-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Detection of differential mitotic cell age in bone marrow CD34(+) cells from patients with myelodysplastic syndrome and acute leukemia by analysis of an epigenetic molecular clock DNA signature.
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pubmed:affiliation |
Department of Hematology, Oncology and Transfusion Medicine, Charité, University Hospital Benjamin Franklin, Berlin, Germany. max.mossner@charite.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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