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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-5-31
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pubmed:abstractText |
Previous work has suggested that an extracellular matrix degrading enzyme-matrix metalloproteinase-2 (MMP-2) plays an important role in the development of muscle atrophy. However, the transcriptional regulation mechanism of MMP-2 in skeletal muscle atrophy remains largely unknown. Using transgenic MMP-2 promoter reporter mice, we have demonstrated that AP-1 and RE-1 binding sites in the MMP-2 promoter region, coupled with increased binding of Fra-1, Fra-2 and AP-2, play a critical role in MMP-2 transcriptional regulation in muscle atrophy. Novel information gained from this study has improved our understanding of in vivo transcriptional regulation of MMP-2 in skeletal muscle atrophy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1090-2104
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pubmed:author |
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pubmed:copyrightInfo |
Published by Elsevier Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
396
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-23
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pubmed:meshHeading |
pubmed-meshheading:20398633-Animals,
pubmed-meshheading:20398633-Chromatin Immunoprecipitation,
pubmed-meshheading:20398633-Disease Models, Animal,
pubmed-meshheading:20398633-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:20398633-Matrix Metalloproteinase 2,
pubmed-meshheading:20398633-Mice,
pubmed-meshheading:20398633-Mice, Transgenic,
pubmed-meshheading:20398633-Muscle, Skeletal,
pubmed-meshheading:20398633-Muscular Atrophy,
pubmed-meshheading:20398633-Promoter Regions, Genetic,
pubmed-meshheading:20398633-Repressor Proteins,
pubmed-meshheading:20398633-Transcription, Genetic,
pubmed-meshheading:20398633-Transcription Factor AP-1
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pubmed:year |
2010
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pubmed:articleTitle |
Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy.
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pubmed:affiliation |
Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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