20398276

Source:http://linkedlifedata.com/resource/pubmed/id/20398276

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021747, umls-concept:C0086418, umls-concept:C1171362, umls-concept:C1513095, umls-concept:C1564682, umls-concept:C1709059
pubmed:dateCreated	2010-4-23
pubmed:abstractText	Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulators of interferon signaling known as suppressors of cytokine signaling (SOCS) in mediating interferon-resistance in human melanoma cells.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA84402, http://linkedlifedata.com/resource/pubmed/grant/K22 CA134551, http://linkedlifedata.com/resource/pubmed/grant/K24 CA93670, http://linkedlifedata.com/resource/pubmed/grant/P01 CA95426, http://linkedlifedata.com/resource/pubmed/grant/P30 CA16058
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100967800
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/SOCS1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/SOCS3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling..., http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2b
pubmed:status	MEDLINE
pubmed:issn	1471-2407
pubmed:author	pubmed-author:BecknellBrianB, pubmed-author:BillMatthew AMA, pubmed-author:CarsonWilliam EWE3rd, pubmed-author:KreinerMelanieM, pubmed-author:LesinskiGregory BGB, pubmed-author:TrefryJohnJ, pubmed-author:YoungGregory SGS, pubmed-author:ZimmererJason MJM
pubmed:issnType	Electronic
pubmed:volume	10
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	142
pubmed:dateRevised	2011-11-17
pubmed:meshHeading	pubmed-meshheading:20398276-Humans, pubmed-meshheading:20398276-Interferon-alpha, pubmed-meshheading:20398276-Interferon-gamma, pubmed-meshheading:20398276-Melanoma, pubmed-meshheading:20398276-Phosphorylation, pubmed-meshheading:20398276-RNA, Small Interfering, pubmed-meshheading:20398276-Recombinant Proteins, pubmed-meshheading:20398276-STAT1 Transcription Factor, pubmed-meshheading:20398276-Signal Transduction, pubmed-meshheading:20398276-Suppressor of Cytokine Signaling Proteins, pubmed-meshheading:20398276-Transfection
pubmed:year	2010
pubmed:articleTitle	Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells.
pubmed:affiliation	Department of Surgery Arthur G, James Cancer Hospital and Richard J, Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.

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