20396999

Source:http://linkedlifedata.com/resource/pubmed/id/20396999

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017337, umls-concept:C0086418, umls-concept:C0872184, umls-concept:C1418449, umls-concept:C1707931
pubmed:issue	7
pubmed:dateCreated	2010-5-27
pubmed:abstractText	Overexpression of PED (also known as PEA15) determines insulin resistance and impaired insulin secretion and may contribute to progression toward type 2 diabetes. Recently, we found that the transcription factor hepatocyte nuclear factor (HNF)-4alpha binds to PED promoter and represses its transcription. However, the molecular details responsible for regulation of PED gene remain unclear.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0006777
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 4, http://linkedlifedata.com/resource/pubmed/chemical/Histones, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Nucleosomes, http://linkedlifedata.com/resource/pubmed/chemical/PEA15 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1432-0428
pubmed:author	pubmed-author:BeguinotFF, pubmed-author:CiccarelliMM, pubmed-author:FormisanoPP, pubmed-author:LongoMM, pubmed-author:MieliGG, pubmed-author:MirraPP, pubmed-author:NigroCC, pubmed-author:RacitiG AGA, pubmed-author:TeperinoRR, pubmed-author:UngaroPP
pubmed:issnType	Electronic
pubmed:volume	53
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1482-92
pubmed:meshHeading	pubmed-meshheading:20396999-Acetylation, pubmed-meshheading:20396999-Animals, pubmed-meshheading:20396999-Blotting, Western, pubmed-meshheading:20396999-Chromatin Assembly and Disassembly, pubmed-meshheading:20396999-Chromatin Immunoprecipitation, pubmed-meshheading:20396999-Epigenesis, Genetic, pubmed-meshheading:20396999-Hep G2 Cells, pubmed-meshheading:20396999-Hepatocyte Nuclear Factor 4, pubmed-meshheading:20396999-Histones, pubmed-meshheading:20396999-Humans, pubmed-meshheading:20396999-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:20396999-Mice, pubmed-meshheading:20396999-Mice, Transgenic, pubmed-meshheading:20396999-Nucleosomes, pubmed-meshheading:20396999-Phosphoproteins, pubmed-meshheading:20396999-Promoter Regions, Genetic, pubmed-meshheading:20396999-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year	2010
pubmed:articleTitle	Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene.
pubmed:affiliation	Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples, 80131, Italy. pungaro@ieos.cnr.it
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't