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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-4-30
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pubmed:abstractText |
This paper reports the synthesis of new derivatives (formed by two indole systems separated by a central moiety) analogous of potent antitumor agents previously described. The activity of the bis-indoles bearing a pyridine core confirms the good result described in the previous paper and compound 4c was chosen for the first in vivo experiment (Hollow Fiber Assay). COMPARE analysis and structure-activity relationships were also considered. Contrary to data reported by other Authors, no correlations were found between antitumor activity and NQO1 induction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:AndreaniAldoA,
pubmed-author:BurnelliSilviaS,
pubmed-author:CalicetiCristianaC,
pubmed-author:Dalla SegaFrancesco VieceliFV,
pubmed-author:GranaiolaMassimilianoM,
pubmed-author:KimW GWG,
pubmed-author:LeoniAlbertoA,
pubmed-author:LocatelliAlessandraA,
pubmed-author:MorigiRitaR,
pubmed-author:PrataCeciliaC,
pubmed-author:RambaldiMirellaM,
pubmed-author:ShoemakerRobert HRH,
pubmed-author:VaroliLucillaL
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pubmed:copyrightInfo |
(c) 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3004-11
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pubmed:meshHeading |
pubmed-meshheading:20395150-Antineoplastic Agents,
pubmed-meshheading:20395150-Cell Line, Tumor,
pubmed-meshheading:20395150-Cell Proliferation,
pubmed-meshheading:20395150-Drug Screening Assays, Antitumor,
pubmed-meshheading:20395150-Humans,
pubmed-meshheading:20395150-Indoles,
pubmed-meshheading:20395150-Inhibitory Concentration 50,
pubmed-meshheading:20395150-Molecular Structure,
pubmed-meshheading:20395150-Neoplasms,
pubmed-meshheading:20395150-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Antitumor activity and COMPARE analysis of bis-indole derivatives.
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pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Via Belmeloro 6, 40126 Bologna, Italy. aldo.andreani@unibo.it
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pubmed:publicationType |
Journal Article
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