|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004391,
umls-concept:C0007600,
umls-concept:C0014239,
umls-concept:C0015127,
umls-concept:C0038435,
umls-concept:C0054130,
umls-concept:C0086418,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C1314792,
umls-concept:C2239176
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|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-4-15
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|
pubmed:abstractText |
Autophagy, a cellular response to stress, plays a role in resistance to chemotherapy in cancer cells. Resistance renders systemic chemotherapy generally ineffective against human hepatocellular carcinoma (HCC). Recently, we reported that the pyruvate analog 3-bromopyruvate (3-BrPA) promoted tumor cell death by targeting GAPDH. In continuance, we investigated the intracellular response of two human HCC cell lines (Hep3B and SK-Hep1) that differ in their status of key apoptotic regulators, p53 and Fas. Methods and
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1791-7530
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
30
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
923-35
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pubmed:meshHeading |
pubmed-meshheading:20393016-Adenosine Triphosphate,
pubmed-meshheading:20393016-Apoptosis,
pubmed-meshheading:20393016-Autophagy,
pubmed-meshheading:20393016-Carcinoma, Hepatocellular,
pubmed-meshheading:20393016-Cell Line, Tumor,
pubmed-meshheading:20393016-Endoplasmic Reticulum,
pubmed-meshheading:20393016-Humans,
pubmed-meshheading:20393016-Liver Neoplasms,
pubmed-meshheading:20393016-Pyruvates,
pubmed-meshheading:20393016-Stress, Physiological
|
|
pubmed:year |
2010
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|
pubmed:articleTitle |
3-Bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines.
|
|
pubmed:affiliation |
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock Building, Room 545, Baltimore, MD 21287, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
