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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-5-4
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pubmed:abstractText |
Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X(7) receptor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3107-11
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20392639-Animals,
pubmed-meshheading:20392639-Anti-Inflammatory Agents,
pubmed-meshheading:20392639-Benzamides,
pubmed-meshheading:20392639-Central Nervous System,
pubmed-meshheading:20392639-Drug Discovery,
pubmed-meshheading:20392639-Humans,
pubmed-meshheading:20392639-Male,
pubmed-meshheading:20392639-Microsomes, Liver,
pubmed-meshheading:20392639-Purinergic P2 Receptor Antagonists,
pubmed-meshheading:20392639-Pyrimidines,
pubmed-meshheading:20392639-Rats,
pubmed-meshheading:20392639-Rats, Sprague-Dawley,
pubmed-meshheading:20392639-Receptors, Purinergic P2,
pubmed-meshheading:20392639-Receptors, Purinergic P2X7,
pubmed-meshheading:20392639-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist.
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pubmed:affiliation |
Department of Medicinal Chemistry, Pfizer St. Louis Research Laboratories, Chesterfield, MO 63017, USA. xiangyang.chen@hotmail.com
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pubmed:publicationType |
Journal Article
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