Linked Life Data

20392545

Source:http://linkedlifedata.com/resource/pubmed/id/20392545

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-5-17
pubmed:abstractText
A series of 10-position substituted nitrogenous heterocyclic aromatic group derivatives of SN-38 were prepared. Most of these compounds possessed lower cytotoxicities than CPT. Compound 13 revealed potent cytotoxicity similar to CPT, and compounds 17, 18, and 19 showed similar cytotoxic activity to topotecan. All of the pyridine salt derivatives (7-16) revealed comparable or superior topo I inhibitory activity in relation to CPT. Ethyl in the 7-position of these compounds can increase the cytotoxicity and inhibitory activity to topo I compared with corresponding pyridine salts CPT derivatives (7a-13a) and simultaneously maintain good water solubility. This result is consistent with the SAR of CPT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1768-3254
pubmed:author
pubmed:copyrightInfo
Crown Copyright (c) 2010. Published by Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3200-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Cytotoxicity and topo I targeting activity of substituted 10--nitrogenous heterocyclic aromatic group derivatives of SN-38.
pubmed:affiliation
Key Laboratory of Forest Plant Ecology (Northeast Forestry University), Ministry of Education, 332# No26 Hexing Road, Harbin city, Heilongjiang Province 150040, PR China. li_qingyong@126.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't