Linked Life Data

20389031

Source:http://linkedlifedata.com/resource/pubmed/id/20389031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2010-6-4
pubmed:abstractText
Heterochromatin patterns were analyzed in the genus Ctenomys from Uruguay which exhibits high karyotype variability. Different amounts and localizations of heterochromatin were observed in species and populations analyzed. While species as C. rionegrensis presented heterochromatic arms in all the chromosomes of the karyotype, other species like C. torquatus showed only few chromosomes with pericentric heterochromatin. At the pachytene stage, bivalents merge in densely stained chromocenters. We detected in these chromocenters the typical highly repeated DNA of this genus after in situ hybridization, the M31 chromodomain through immunofluorescence as well as dense Giemsa staining after C-banding. In species that present low amounts of heterochromatin, only 1 or 2 chromocenters were observed in which bivalents merge as observed in C. rionegrensis. After BRCA1 immunodetection we observed in early pachytene cells positive spots located over heterochromatic chromocenters that strongly suggest heterochromatic DNA repair. Mechanical stress mainly due to increasing chromatin compactness before metaphase I might be a mechanism to spread heterochromatin between different chromosomes within a karyotype.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1424-859X
pubmed:author
pubmed:copyrightInfo
Copyright 2010 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
152-61
pubmed:dateRevised
2011-7-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Possible heterochromatin horizontal spread through non-homologous chromosome associations in pachytene chromocenters of Ctenomys Rodents.
pubmed:affiliation
Sección Genética Evolutiva, Instituto de Biología, Montevideo, Uruguay. anovello@fcien.edu.uy
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't