Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-4-14
pubmed:abstractText
Increasing number of evidence suggest that gastric mucosal protection can be induced also centrally. Several neuropeptides, such as TRH, amylin, adrenomedullin, enkephalin, beta-endorphin, nociceptin, nocistatin, ghrelin or orexin given centrally induce gastroprotection and the dorsal vagal complex and vagal nerve may play prominent role in this centrally initiated effect. Since also cannabinoid receptors are present in the dorsal vagal complex, we aimed to study whether activation of central cannabinoid receptors result in gastric mucosal defense and whether there is an interaction between cannabinoids and endogenous opioids. Gastric mucosal damage was induced by 100% ethanol in rats. The cannabinoids were given intravenously (i.v.) or intracerebroventricularly (i.c.v.), while the antagonists were given i.c.v or intracisternally (i.c.). Gastric lesions were evaluated macroscopically 60 min later. Anandamide, methanandamide and WIN55,212-2 reduced ethanol-induced mucosal lesions after both peripheral (0.28-5.6 micromol/kg, 0.7-5.6 micromol/kg and 0.05-0.2 mumol/kg i.v., respectively) and central (2.9-115 nmol/rat, 0.27-70 nmol/rat and 1.9-38 nmol/rat i.c.v., respectively) administration. The gastroprotective effect of anandamide and methanandamide given i.c.v. or i.v.was reversed by the CB(1) receptor antagonist SR141716A (2.16 nmol i.c.v.). Naloxone (27.5 nmol i.c.v.) also antagonized the effect of i.c.v. or i.v. injected anandamide and WIN55,212-2, but less affected that of methanandamide. The gastroprotective effect of anandamide was diminished also by endomorphin-2 antiserum. In conclusion it was first demonstrated that activation of central CB(1) receptors results in gastroprotective effect. The effect is mediated at least partly by endogenous opioids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid, http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cannabinoids, http://linkedlifedata.com/resource/pubmed/chemical/Endocannabinoids, http://linkedlifedata.com/resource/pubmed/chemical/Ethanol, http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides, http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cannabinoid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, http://linkedlifedata.com/resource/pubmed/chemical/endomorphin 2
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1899-1505
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
60 Suppl 7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-100
pubmed:meshHeading
pubmed-meshheading:20388951-Analgesics, Opioid, pubmed-meshheading:20388951-Animals, pubmed-meshheading:20388951-Anti-Ulcer Agents, pubmed-meshheading:20388951-Cannabinoids, pubmed-meshheading:20388951-Dose-Response Relationship, Drug, pubmed-meshheading:20388951-Endocannabinoids, pubmed-meshheading:20388951-Ethanol, pubmed-meshheading:20388951-Gastric Mucosa, pubmed-meshheading:20388951-Hydrogen-Ion Concentration, pubmed-meshheading:20388951-Injections, Intraventricular, pubmed-meshheading:20388951-Male, pubmed-meshheading:20388951-Narcotic Antagonists, pubmed-meshheading:20388951-Neuropeptides, pubmed-meshheading:20388951-Oligopeptides, pubmed-meshheading:20388951-Rats, pubmed-meshheading:20388951-Rats, Wistar, pubmed-meshheading:20388951-Receptor, Cannabinoid, CB1, pubmed-meshheading:20388951-Receptors, Cannabinoid, pubmed-meshheading:20388951-Receptors, Opioid, pubmed-meshheading:20388951-Severity of Illness Index, pubmed-meshheading:20388951-Stomach Ulcer
pubmed:year
2009
pubmed:articleTitle
Analysis of the effect of neuropeptides and cannabinoids in gastric mucosal defense initiated centrally in the rat.
pubmed:affiliation
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't