Linked Life Data

20388058

Source:http://linkedlifedata.com/resource/pubmed/id/20388058

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-10-14
pubmed:abstractText
The inflammatory bowel diseases ulcerative colitis and Crohn's disease (CD) are heterogeneous syndromes representing the outcome of the colliding influences of shared and distinct genetic risk factors, environmental or lifestyle modifiers and immune effector mechanisms. Identification of specific genetic risk factors has provided a glimpse of potential pathways of tissue damage. Defective mucosal clearance of bacteria (commensals and pathogens), including phagocytic cell dysfunction, appears to be common in CD, but distinct inputs to a final common pathway of tissue damage may account for heterogeneity. Regardless of the genetic risk, the primacy of environmental or lifestyle risk factors is evident and can be linked to changes in the gut microbiota, particularly in early life. Improved understanding of the molecular basis of host–microbe interactions in the gut promises novel therapeutic strategies. Thus, the emerging drug therapy for patients with these diseases is moving from trials of empiric possibilities to rational drug design with exciting prospects already at hand.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1607-842X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
463-77
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Inflammatory bowel disease—from mechanisms to treatment strategies.
pubmed:affiliation
Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't