Linked Life Data

20387253

Source:http://linkedlifedata.com/resource/pubmed/id/20387253

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-4-13
pubmed:abstractText
Sp1 is a ubiquitous nuclear factor that plays a key role in maintaining basal transcription of 'house-keeping' genes. It has been demonstrated that Sp1 is involved in many cellular process, e.g.cell growth and differentiation. Sp1 plays an extremely important role in growth and metastasis of many tumors by regulating oncogenes, tumor suppressor genes, cell cycle control molecules, growth-related signal transductions, angiogenesis-related factors, as well as apoptosis. The expression of Sp1 and its activity are strictly regulated. Mechanisms include the modulation of Sp1 and interactions between Sp1 and other molecules. New treatment with Sp1 as the target will bring profound impacts on the strategy of clinical chemotherapy of tumor.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1008-9292
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-20
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[Research progress on relationship between transcription factor Sp1 and tumor].
pubmed:affiliation
Department of Pathology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't