Linked Life Data

20386787

Source:http://linkedlifedata.com/resource/pubmed/id/20386787

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-4-13
pubmed:abstractText
Genetic polymorphisms in the interleukin-6 (IL-6) gene are associated with bone homeostasis and diseases characterized by bone loss. The aim of this study was to investigate the correlation between the IL-6-572C/G polymorphism and the risk of chronic periodontitis in a Chinese Han population. The IL-6-572C/G polymorphism was genotyped in 93 patients suffering from chronic periodontitis and 96 control subjects by polymerase chain reaction-restriction fragment length polymorphism. DNA was extracted from the peripheral blood of patients and control subjects and amplified using a polymerase chain reaction. IL-6 genotypes were identified using gel electrophoresis. The IL-6-572 GG genotype and the G allele were more frequent in chronic periodontitis patients than in control subjects (P<.05). When compared with the CC genotype, the odds ratio for chronic periodontitis was 1.88 (95% confidence interval, 1.04 to 3.40; P<.05) for the CG+GG genotype. The frequency of the -572CG+GG genotype was significantly different between the control group and the group with chronic periodontitis. Therefore, the IL-6-572C/G polymorphism may contribute to the susceptibility to chronic periodontitis in the Chinese Han population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0198-7569
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-5
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Correlation between an interleukin-6 -572C/G polymorphism and chronic periodontitis.
pubmed:affiliation
Dental College, Zhengzhou University, and Department of Stomatology, Henan Provincial People's Hospital, Henan, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't