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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-18
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pubmed:databankReference |
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pubmed:abstractText |
A clinical strain of Acinetobacter calcoaceticus resistant to carbapenems was isolated from a blood culture sample from an inpatient in a hospital in Madrid (Spain) during a large outbreak of infection (affecting more than 300 inpatients), caused by a multidrug-resistant Acinetobacter baumannii clone. The carbapenem resistance in both the A. calcoaceticus and A. baumannii clones was due to a bla(OXA-24) gene harbored in different plasmids. The plasmids were fully sequenced, revealing the presence of site-specific recombination binding sites putatively involved in mobilization of the bla(OXA-24) gene. Comparison of plasmids contained in the two strains revealed possible horizontal transmission of resistance genes between the Acinetobacter species.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1098-6596
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2724-7
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pubmed:dateRevised |
2011-3-3
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pubmed:meshHeading |
pubmed-meshheading:20385865-Acinetobacter,
pubmed-meshheading:20385865-Acinetobacter Infections,
pubmed-meshheading:20385865-Acinetobacter baumannii,
pubmed-meshheading:20385865-Acinetobacter calcoaceticus,
pubmed-meshheading:20385865-Bacterial Proteins,
pubmed-meshheading:20385865-Base Sequence,
pubmed-meshheading:20385865-Cross Infection,
pubmed-meshheading:20385865-DNA-Binding Proteins,
pubmed-meshheading:20385865-Disease Outbreaks,
pubmed-meshheading:20385865-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:20385865-Gene Transfer, Horizontal,
pubmed-meshheading:20385865-Genes, Bacterial,
pubmed-meshheading:20385865-Humans,
pubmed-meshheading:20385865-Molecular Epidemiology,
pubmed-meshheading:20385865-Molecular Sequence Data,
pubmed-meshheading:20385865-Plasmids,
pubmed-meshheading:20385865-Recombination, Genetic,
pubmed-meshheading:20385865-Spain,
pubmed-meshheading:20385865-Species Specificity,
pubmed-meshheading:20385865-beta-Lactam Resistance,
pubmed-meshheading:20385865-beta-Lactamases
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pubmed:year |
2010
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pubmed:articleTitle |
OXA-24 carbapenemase gene flanked by XerC/XerD-like recombination sites in different plasmids from different Acinetobacter species isolated during a nosocomial outbreak.
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pubmed:affiliation |
Laboratorio de Microbiología, Complejo Hospitalario Universitario A Coruña, Xubias s/n, 3 Planta Ed. Sur, 15006 La Coruña, Spain.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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