| pubmed-article:20385759 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0042629 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20385759 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20385759 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20385759 | pubmed:dateCreated | 2010-5-20 | lld:pubmed |
| pubmed-article:20385759 | pubmed:abstractText | Strain AM-19226 is a pathogenic non-O1/non-O139 serogroup Vibrio cholerae strain that does not encode the toxin-coregulated pilus or cholera toxin but instead causes disease using a type three secretion system (T3SS). Two genes within the T3SS pathogenicity island, herein named vttR(A) (locus tag A33_1664) and vttR(B) (locus tag A33_1675), are predicted to encode proteins that show similarity to the transcriptional regulator ToxR, which is found in all strains of V. cholerae. Strains with a deletion of vttR(A) or vttR(B) showed attenuated colonization in vivo, indicating that the T3SS-encoded regulatory proteins play a role in virulence. lacZ transcriptional reporter fusions to intergenic regions upstream of genes encoding the T3SS structural components identified growth in the presence of bile as a condition that modulates gene expression. Under this condition, VttR(A) and VttR(B) were necessary for maximal gene expression. In contrast, growth in bile did not substantially alter the expression of a reporter fusion to the vopF gene, which encodes an effector protein. Increased vttR(B) reporter fusion activity was observed in a DeltavttR(B) strain background, suggesting that VttR(B) may regulate its own expression. The collective results are consistent with the hypothesis that T3SS-encoded regulatory proteins are essential for pathogenesis and control the expression of selected T3SS genes. | lld:pubmed |
| pubmed-article:20385759 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20385759 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20385759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20385759 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20385759 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20385759 | pubmed:issn | 1098-5522 | lld:pubmed |
| pubmed-article:20385759 | pubmed:author | pubmed-author:DziejmanMiche... | lld:pubmed |
| pubmed-article:20385759 | pubmed:author | pubmed-author:HamiltonElain... | lld:pubmed |
| pubmed-article:20385759 | pubmed:author | pubmed-author:TamVincentV | lld:pubmed |
| pubmed-article:20385759 | pubmed:author | pubmed-author:AlamAshfaqulA | lld:pubmed |
| pubmed-article:20385759 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20385759 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:20385759 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20385759 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20385759 | pubmed:pagination | 2554-70 | lld:pubmed |
| pubmed-article:20385759 | pubmed:dateRevised | 2011-4-6 | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
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| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
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| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:meshHeading | pubmed-meshheading:20385759... | lld:pubmed |
| pubmed-article:20385759 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20385759 | pubmed:articleTitle | vttRA and vttRB Encode ToxR family proteins that mediate bile-induced expression of type three secretion system genes in a non-O1/non-O139 Vibrio cholerae strain. | lld:pubmed |
| pubmed-article:20385759 | pubmed:affiliation | Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. | lld:pubmed |
| pubmed-article:20385759 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20385759 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20385759 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20385759 | lld:pubmed |
