|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2010-5-24
|
|
pubmed:abstractText |
Adrenal insufficiency is a common disorder among cirrhotic patients. Adrenal function is usually assessed with serum total cortisol assays. Free cortisol (active fraction) represents only 10% of serum total cortisol, the remaining 90% being linked to cortisol-binding globulin (CBG) and albumin. In cirrhotic patients, the synthesis of these proteins is reduced, which could lead to an overestimation of the prevalence of adrenal insufficiency. Salivary cortisol assessment adequately reflects free cortisol plasma concentration. However, this method has never been validated in cirrhotic patients. The objectives of this report were to assess the following parameters by a prospective observational study: (1) correlation between salivary, serum total and free cortisol, (2) adrenal insufficiency prevalence using salivary and serum assays, (3) parameters associated with a discrepancy between both tests, and (4) adrenal insufficiency risk factors among cirrhotic patients.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0168-8278
|
|
pubmed:author |
pubmed-author:BennaniAbdelhaiA,
pubmed-author:Bonnefont-RousselotDominiqueD,
pubmed-author:BourrierAnneA,
pubmed-author:FullaYvonneY,
pubmed-author:GalboisArnaudA,
pubmed-author:MassardJulienJ,
pubmed-author:PoynardThierryT,
pubmed-author:ReignierStéphanieS,
pubmed-author:RudlerMarikaM,
pubmed-author:ThabutDominiqueD,
pubmed-author:ThibaultVincentV
|
|
pubmed:copyrightInfo |
Copyright 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
52
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
839-45
|
|
pubmed:dateRevised |
2011-3-23
|
|
pubmed:meshHeading |
pubmed-meshheading:20385427-Adrenal Insufficiency,
pubmed-meshheading:20385427-Adrenocorticotropic Hormone,
pubmed-meshheading:20385427-Adult,
pubmed-meshheading:20385427-Carrier Proteins,
pubmed-meshheading:20385427-Female,
pubmed-meshheading:20385427-Hormones,
pubmed-meshheading:20385427-Humans,
pubmed-meshheading:20385427-Hydrocortisone,
pubmed-meshheading:20385427-Liver Cirrhosis,
pubmed-meshheading:20385427-Male,
pubmed-meshheading:20385427-Middle Aged,
pubmed-meshheading:20385427-Prevalence,
pubmed-meshheading:20385427-Prospective Studies,
pubmed-meshheading:20385427-Reproducibility of Results,
pubmed-meshheading:20385427-Risk Factors,
pubmed-meshheading:20385427-Saliva,
pubmed-meshheading:20385427-Serum Albumin
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Assessment of adrenal function in cirrhotic patients: salivary cortisol should be preferred.
|
|
pubmed:affiliation |
Université Pierre et Marie Curie, Service d'hépato-gastroentérologie, Hôpital de la Pitié-Salpêtrière (AP-HP), Paris, France.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't,
Validation Studies
|
