Source:http://linkedlifedata.com/resource/pubmed/id/20384594
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-11-5
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| pubmed:abstractText |
clinical observations suggest that alternans in action potential (AP) characteristics presages breakdown of normal ordered cardiac electrical activity culminating in ventricular arrhythmogenesis. We compared such temporal nonuniformities in monophasic action potential (MAP) waveforms in left (LV) and right ventricular (RV) epicardia and endocardia of Langendorff-perfused murine wild-type (WT), and Scn5a(+/-) hearts modelling Brugada syndrome (BrS) for the first time.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1748-1716
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
200
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
129-46
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| pubmed:dateRevised |
2011-7-22
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| pubmed:meshHeading |
pubmed-meshheading:20384594-Action Potentials,
pubmed-meshheading:20384594-Animals,
pubmed-meshheading:20384594-Brugada Syndrome,
pubmed-meshheading:20384594-Cardiac Pacing, Artificial,
pubmed-meshheading:20384594-Electrophysiology,
pubmed-meshheading:20384594-Heart,
pubmed-meshheading:20384594-Mice,
pubmed-meshheading:20384594-Mice, Mutant Strains,
pubmed-meshheading:20384594-Organ Culture Techniques,
pubmed-meshheading:20384594-Sodium Channels
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| pubmed:year |
2010
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| pubmed:articleTitle |
Regional variations in action potential alternans in isolated murine Scn5a (+/-) hearts during dynamic pacing.
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| pubmed:affiliation |
Physiological Laboratory, University of Cambridge, Cambridge.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|