Source:http://linkedlifedata.com/resource/pubmed/id/20384293
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2010-5-28
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pubmed:abstractText |
Bioassay-guided fractionation of the roots of Litsea hypophaea led to the isolation of seven new butanolides, namely, litseakolides H-N (1-7), all with the 3R,4S configuration, as well as three new biarylpropanoids, hypophaone (8), hypophaol (9), and hypophane (10), and 15 known compounds. The structures of 1-10 were determined by means of spectroscopic analysis. Litseakolide L (5) and N-trans-feruloylmethoxytyramine (11) showed antitubercular activity against Mycobacterium tuberculosis strain H(37)Rv, with MIC values of 25 and 1.6 microg/mL, respectively.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1520-6025
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
890-6
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pubmed:meshHeading |
pubmed-meshheading:20384293-4-Butyrolactone,
pubmed-meshheading:20384293-Antitubercular Agents,
pubmed-meshheading:20384293-Litsea,
pubmed-meshheading:20384293-Microbial Sensitivity Tests,
pubmed-meshheading:20384293-Molecular Structure,
pubmed-meshheading:20384293-Mycobacterium tuberculosis,
pubmed-meshheading:20384293-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:20384293-Plant Roots,
pubmed-meshheading:20384293-Stereoisomerism,
pubmed-meshheading:20384293-Taiwan
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pubmed:year |
2010
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pubmed:articleTitle |
Secondary metabolites from the roots of Litsea hypophaea and their antitubercular activity.
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pubmed:affiliation |
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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