Linked Life Data

20383747

Source:http://linkedlifedata.com/resource/pubmed/id/20383747

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-21
pubmed:abstractText
Docosahexaenoic acid (DHA) is one kind of ?-3 polyunsaturated fatty acids (PUFAs) and plays an important role in lipid metabolism. In this research, mice were daily intragastric administrated with DHA for 3 weeks. Subcutaneous adipose tissue and liver were separated every week, RNA was extracted. Peroxisome proliferator-activated receptor (PPAR?), Sterol regulatory element binding protein-1c (SREBP-1c), Fatty acid synthetase (FAS), Hormone sensitive lipase (HSL) and triglyceride hydrolase TGH genes expression were detected by quantitative PCR. Data showed that, DHA up-regulated PPAR?, HSL and TGH in adipose tissue, but it had no effect on SREBP-1c and FAS expression. However, in liver there were some differences in regulating these genes. PPAR?, SREBP-1c and FAS were down-regulated, HSL was up-regulated and TGH had no change. These results indicated that DHA played different regulating roles in lipid metabolism in different tissues. In adipose tissue, DHA increased the expression of lipogenesis and lipolysis genes. In liver lipogenesis genes were decreased, but lipolysis genes were increased by DHA. In conclusion, DHA could reduce body fat mass through regulating lipogenesis and lipolysis genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1573-4978
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
731-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
DHA regulates lipogenesis and lipolysis genes in mice adipose and liver.
pubmed:affiliation
College of Animal Science and Technology, Northwest A&F University, 712100, Yangling, Shaanxi, China. sunchao2775@163.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't