Linked Life Data

20383154

Source:http://linkedlifedata.com/resource/pubmed/id/20383154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-5-7
pubmed:abstractText
Inflammatory pain, such as arthritis pain, is a growing health problem. Inflammatory pain is generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by side effects. Recently, resolvins, a unique family of lipid mediators, including RvE1 and RvD1 derived from omega-3 polyunsaturated fatty acid, have shown marked potency in treating disease conditions associated with inflammation. Here we report that peripheral (intraplantar) or spinal (intrathecal) administration of RvE1 or RvD1 in mice potently reduces inflammatory pain behaviors induced by intraplantar injection of formalin, carrageenan or complete Freund's adjuvant (CFA), without affecting basal pain perception. Intrathecal RvE1 injection also inhibits spontaneous pain and heat and mechanical hypersensitivity evoked by intrathecal capsaicin and tumor necrosis factor-alpha (TNF-alpha). RvE1 has anti-inflammatory activity by reducing neutrophil infiltration, paw edema and proinflammatory cytokine expression. RvE1 also abolishes transient receptor potential vanilloid subtype-1 (TRPV1)- and TNF-alpha-induced excitatory postsynaptic current increases and TNF-alpha-evoked N-methyl-D-aspartic acid (NMDA) receptor hyperactivity in spinal dorsal horn neurons via inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. Thus, we show a previously unknown role for resolvins in normalizing the spinal synaptic plasticity that has been implicated in generating pain hypersensitivity. Given the potency of resolvins and the well-known side effects of opioids and COX inhibitors, resolvins may represent new analgesics for treating inflammatory pain.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/NS67686, http://linkedlifedata.com/resource/pubmed/grant/R01 DE017794-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DE019938-01, http://linkedlifedata.com/resource/pubmed/grant/R01 DE019938-03, http://linkedlifedata.com/resource/pubmed/grant/R01 DK074448-05, http://linkedlifedata.com/resource/pubmed/grant/R01 GM038765-25, http://linkedlifedata.com/resource/pubmed/grant/R01 NS054932-03, http://linkedlifedata.com/resource/pubmed/grant/R01 NS054932-04, http://linkedlifedata.com/resource/pubmed/grant/R01 NS067686-01, http://linkedlifedata.com/resource/pubmed/grant/R01-DE019938, http://linkedlifedata.com/resource/pubmed/grant/R01-DE17794, http://linkedlifedata.com/resource/pubmed/grant/R01-DK074448, http://linkedlifedata.com/resource/pubmed/grant/R01-NS54362, http://linkedlifedata.com/resource/pubmed/grant/R37 GM038765-23, http://linkedlifedata.com/resource/pubmed/grant/R37 GM38765
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1546-170X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
592-7, 1p following 597
pubmed:dateRevised
2011-5-12
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.
pubmed:affiliation
Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural