20382166

Source:http://linkedlifedata.com/resource/pubmed/id/20382166

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0037791, umls-concept:C0205171, umls-concept:C0282411, umls-concept:C0392747, umls-concept:C0680218, umls-concept:C1511539, umls-concept:C1554963
pubmed:issue	4
pubmed:dateCreated	2010-5-24
pubmed:abstractText	Covalent modification(s) are required in many signaling pathways. It has been discussed from a deterministic viewpoint that dual covalent modification is more favorable than single covalent modification for signaling specificity. However, whether this conclusion is feasible in stochastic situation has not yet been studied. To study the role of covalent modification in the specificity of a stochastic signaling pathway, we here simulate the dynamics of a transiently stimulated signaling pathway, considering the influence of the stochasticity arising from the low molecule number of reactants. It turns out that the specificity of dual covalent modification would be worse than that of single covalent modification when the number of molecules is in some biologically plausible range. We further discuss some factors that have potential influence on specificity, such as the rates of the upstream reaction cycle of the covalent modification(s), the duration and the magnitude of the transient stimulus. Our numerical results indicate that whether dual or single covalent modification(s) is better in specificity also depends on these factors. Superiority of single covalent modification in specificity would arise if the stimulus is weak and transient, or if it is embedded downstream of a reaction whose activation rate is slow while deactivation rate is fast. The relevance of these conclusions to signal transduction is briefly discussed.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0376342
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1095-8541
pubmed:author	pubmed-author:ZhangLupingL, pubmed-author:ZhaoGangG
pubmed:copyrightInfo	Copyright 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType	Electronic
pubmed:day	21
pubmed:volume	264
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1111-9
pubmed:meshHeading	pubmed-meshheading:20382166-Computer Simulation, pubmed-meshheading:20382166-Kinetics, pubmed-meshheading:20382166-Signal Transduction, pubmed-meshheading:20382166-Stochastic Processes
pubmed:year	2010
pubmed:articleTitle	Superiority of single covalent modification in specificity: from deterministic to stochastic viewpoint.
pubmed:affiliation	Institute of Complex Biodynamics, Jiangxi Blue Sky University, Ziyang Road #115, Nanchang, Jiangxi 330098, People's Republic of China.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't