Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1991-6-28
|
| pubmed:abstractText |
The effect of increasing time of hemorrhage-induced hypotension on basal splanchnic prostanoid (PG) release was examined. Male Sprague-Dawley rats were anesthetized and hemorrhaged to 30 mm Hg for 30, 60, or 120 min (SK-30, SK-60, SK-120 groups). Following shock, the superior mesenteric artery and its end organ intestine (SV + SI) was cannulated and perfused in vitro with Krebs buffer at 3 ml/min. Basal SV + SI release of 6-keto-PGF1 alpha (6-keto), PGE2, and thromboxane B2 (TxB2) was measured in the SK groups by radioimmunoassay after 15, 30, 60, 90, and 120 min of perfusion and compared to sham-operated controls (SM-30, SM-60, and SM-120 groups). 6-Keto was the major PG released from the sham SV + SI groups and was two- to sixfold higher than PGE2 or TxB2 release. Acute shock for 30 min increased SV + SI 6-keto release threefold or higher than the SM-30 group after 15-90 min of perfusion. Acute shock for 60 or 120 min lowered all PG release below SM-60 and SM-120 levels. These data confirmed our earlier study which showed that the SV + SI attempted to compensate for acute hemorrhagic shock for 30 min by increased release of prostacyclin, a potent endogenous vasodilator. The present study showed that the capacity of the SV + SI to increase endogenous prostacyclin release following hemorrhagic shock was limited by the time duration of the hypotension.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
50
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
417-20
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2038178-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:2038178-Animals,
pubmed-meshheading:2038178-Dinoprostone,
pubmed-meshheading:2038178-Epoprostenol,
pubmed-meshheading:2038178-Intestines,
pubmed-meshheading:2038178-Male,
pubmed-meshheading:2038178-Mesenteric Arteries,
pubmed-meshheading:2038178-Rats,
pubmed-meshheading:2038178-Rats, Inbred Strains,
pubmed-meshheading:2038178-Shock, Hemorrhagic,
pubmed-meshheading:2038178-Time Factors,
pubmed-meshheading:2038178-Viscera
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Prolonged hemorrhagic shock decreases splanchnic prostacyclin synthesis.
|
| pubmed:affiliation |
Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75216.
|
| pubmed:publicationType |
Journal Article
|