20380722

Source:http://linkedlifedata.com/resource/pubmed/id/20380722

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0032200, umls-concept:C0040690, umls-concept:C0127400, umls-concept:C0220781, umls-concept:C0224522, umls-concept:C0333348, umls-concept:C1363844, umls-concept:C1883254
pubmed:issue	2
pubmed:dateCreated	2010-6-22
pubmed:abstractText	The objective of this study was to model the effects of transforming growth factor beta (TGF-beta) and platelet-derived growth factor (PDGF), both present in rheumatoid arthritis (RA) synovia, on the behavior of fibroblast-like synoviocytes (FLS) in response to pro-inflammatory cytokine (interleukin (IL)1beta, tumor necrosis factor-alpha (TNFalpha)) challenge.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101154438
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta, http://linkedlifedata.com/resource/pubmed/chemical/imatinib, http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor BB
pubmed:status	MEDLINE
pubmed:issn	1478-6362
pubmed:author	pubmed-author:BoyleDavid LDL, pubmed-author:CorrMaripatM, pubmed-author:RosengrenSannaS
pubmed:issnType	Electronic
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	R65
pubmed:dateRevised	2010-9-28
pubmed:meshHeading	pubmed-meshheading:20380722-Cells, Cultured, pubmed-meshheading:20380722-Cytokines, pubmed-meshheading:20380722-Drug Synergism, pubmed-meshheading:20380722-Fibroblasts, pubmed-meshheading:20380722-Gene Expression, pubmed-meshheading:20380722-Humans, pubmed-meshheading:20380722-Matrix Metalloproteinases, pubmed-meshheading:20380722-Piperazines, pubmed-meshheading:20380722-Platelet-Derived Growth Factor, pubmed-meshheading:20380722-Protein Kinase Inhibitors, pubmed-meshheading:20380722-Pyrimidines, pubmed-meshheading:20380722-RNA, Messenger, pubmed-meshheading:20380722-Signal Transduction, pubmed-meshheading:20380722-Synovial Membrane, pubmed-meshheading:20380722-Transforming Growth Factor beta
pubmed:year	2010
pubmed:articleTitle	Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes.
pubmed:affiliation	Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0656, USA.

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