Linked Life Data

20379887

Source:http://linkedlifedata.com/resource/pubmed/id/20379887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-4-9
pubmed:abstractText
Insulin-like growth factors are crucial in cellular growth, differentiation, and reproduction by mediating many of the actions of growth hormone in chickens. To determine whether insulin-like growth factors genes (IGFs) are associated with important economic traits in chicken or not, we herein analyzed the association between two single nucleotide polymorphisms (SNPs) within IGF1 and IGF2 and twenty-seven growth, body measurement, carcass, and reproduction traits in two Chinese native breeds, i.e., Beijing You and Silkies. With marker-trait association analysis, we found that SNP IGF1-PstI, within the 5' flanking region of IGF1, was significantly associated with body weight at 8 (BW8), 10 (BW10), and 13 (BW13) wk of age; and shank length (SL13) and shank circumference (SC13) at 13 wk of age in Silkie population (P < 0.05). The SNP IGF2-MspI within the exon2 of IGF2 showed a significant association with body weight (BW17) and carcass weight (CW17) at 17 wk of age in Beijing You population (P < 0.05). Our findings implied that the SNPs within IGF1 and IGF2 genes could be in linkage disequilibrium with the actual causative mutations that affect growth and carcass traits.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1532-2378
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-13
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Evaluation of the IGFs (IGF1 and IGF2) genes as candidates for growth, body measurement, carcass, and reproduction traits in Beijing You and Silkie chickens.
pubmed:affiliation
Department of Animal Genetics and Breeding, College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, China Agricultural University, Beijing, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't