Source:http://linkedlifedata.com/resource/pubmed/id/20377806
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-4-9
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| pubmed:abstractText |
Insufficient platelet function suppression by aspirin is a predictor of cardiovascular events in high-risk patients. The authors assessed the impact of obesity on platelet responsiveness before and after 2 weeks of aspirin 81 mg/d in 2014 people. Obese individuals had greater baseline platelet reactivity. Comparing obese and nonobese individuals after aspirin therapy, results for aggregometry to collagen were 6.7 vs 6.1 ohms, P=.008; aggregometry to adenosine diphosphate were 13.1 vs 11.8 ohms,P<.0001; aggregometry to arachidonic acid (AA) were 4.9% vs 8.3% nonzero aggregation, P=.002; urinary excretion of 11-dehydro-thromboxane B2 (Tx-M) were 4.9% vs 8.3% nonzero aggregation, P=.002; and aspirin resistance were 26.% vs 20.5%, P=.002; respectively. These remained significantly different for AA aggregation and Tx-M excretion after adjustment for covariates. Obese individuals have greater native platelet reactivity and retain greater reactivity after suppression by aspirin.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1751-7141
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
13
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
56-62
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| pubmed:meshHeading |
pubmed-meshheading:20377806-Adult,
pubmed-meshheading:20377806-Arachidonic Acid,
pubmed-meshheading:20377806-Aspirin,
pubmed-meshheading:20377806-Blood Platelets,
pubmed-meshheading:20377806-Cardiovascular Diseases,
pubmed-meshheading:20377806-Case-Control Studies,
pubmed-meshheading:20377806-Collagen,
pubmed-meshheading:20377806-Drug Resistance,
pubmed-meshheading:20377806-Female,
pubmed-meshheading:20377806-Humans,
pubmed-meshheading:20377806-Linear Models,
pubmed-meshheading:20377806-Logistic Models,
pubmed-meshheading:20377806-Male,
pubmed-meshheading:20377806-Middle Aged,
pubmed-meshheading:20377806-Multivariate Analysis,
pubmed-meshheading:20377806-Obesity,
pubmed-meshheading:20377806-Phenotype,
pubmed-meshheading:20377806-Platelet Aggregation,
pubmed-meshheading:20377806-Platelet Aggregation Inhibitors,
pubmed-meshheading:20377806-Platelet Function Tests,
pubmed-meshheading:20377806-Time Factors
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| pubmed:year |
2010
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| pubmed:articleTitle |
Effect of obesity on platelet reactivity and response to low-dose aspirin.
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| pubmed:affiliation |
Department of Population Medicine, Harvard Medical School, Boston, MA, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|