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rdf:type |
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lifeskim:mentions |
umls-concept:C0013355,
umls-concept:C0017262,
umls-concept:C0085236,
umls-concept:C0185117,
umls-concept:C0334227,
umls-concept:C0597357,
umls-concept:C0599333,
umls-concept:C0684249,
umls-concept:C1516213,
umls-concept:C1709694,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2010-4-8
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pubmed:abstractText |
Functional evidence suggests that opioid peptides such as dynorphin are involved in the regulation of airway macrophage functions and of human cancer growth. However, anatomical evidence for components of a putative dynorphin network within lung cancer patients is scarce. Tissue from lung cancer patients was examined immunohistochemically for all components of a local dynorphin (DYN) network. Double immunofluorescence microscopy analysis revealed colocalization of the opioid precursor PDYN with its end-product DYN, and key processing enzymes prohormone convertases 1 and 2 and carboxypeptidase E, as well as the kappa-opioid receptor (KOR) within alveolar macrophages and cancerous cells in varying degrees among patients. Moreover, chromograninA-immunoreactive pulmonary neuroendocrine cells expressing DYN were close to substance P- and KOR-immunoreactive sensory nerves. Our findings give a first hint of a neuroanatomical basis for a peripheral DYN network, conceivably regulating pulmonary, immune and cell-proliferative functions within the human lung, most likely in a paracrine/autocrine fashion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carboxypeptidase H,
http://linkedlifedata.com/resource/pubmed/chemical/Dynorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Proprotein Convertase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Proprotein Convertase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/preproenkephalin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1699-5848
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
755-64
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pubmed:meshHeading |
pubmed-meshheading:20376782-Aged,
pubmed-meshheading:20376782-Bronchi,
pubmed-meshheading:20376782-Carboxypeptidase H,
pubmed-meshheading:20376782-Carcinoma,
pubmed-meshheading:20376782-Dynorphins,
pubmed-meshheading:20376782-Enkephalins,
pubmed-meshheading:20376782-Female,
pubmed-meshheading:20376782-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:20376782-Humans,
pubmed-meshheading:20376782-Immunoenzyme Techniques,
pubmed-meshheading:20376782-Lung Neoplasms,
pubmed-meshheading:20376782-Macrophages, Alveolar,
pubmed-meshheading:20376782-Male,
pubmed-meshheading:20376782-Microscopy, Fluorescence,
pubmed-meshheading:20376782-Middle Aged,
pubmed-meshheading:20376782-Neurotransmitter Agents,
pubmed-meshheading:20376782-Proprotein Convertase 1,
pubmed-meshheading:20376782-Proprotein Convertase 2,
pubmed-meshheading:20376782-Protein Precursors,
pubmed-meshheading:20376782-Receptors, Opioid, kappa,
pubmed-meshheading:20376782-Respiratory Mucosa,
pubmed-meshheading:20376782-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Dynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patients.
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pubmed:affiliation |
Department of Anesthesiology and Intensive Care Medicine, Charité-Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charite Mitte, Berlin, Germany.
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pubmed:publicationType |
Journal Article
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