Linked Life Data

20374839

Source:http://linkedlifedata.com/resource/pubmed/id/20374839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-4-8
pubmed:abstractText
The actinin-associated LIM protein (ALP) is co-localized with alpha-actinin at the Z-discs and plays a critical role in the integration of cytoskeletal architecture and transcriptional regulation. Here we report that five isoforms of the porcine ALP were generated in skeletal muscle by alternative splicing. All of ALP isoforms were predominantly expressed in skeletal muscle except for ALP2. These isoforms had different expression profiles during the prenatal and postnatal period of the porcine skeletal muscle development and between the two breeds. Moreover, ALP1 and ALP3 were expressed at higher levels in soleus and masseter muscles compared with longissimus dorsi and bicepsfemoris muscles in Yorkshire pigs. Expression analysis in porcine satellite cells showed that all isoforms were induced in differentiated porcine satellite cells, suggesting a role of them in myogenic differentiation. These results provide new insight into roles of regulation at level of splicing of the ALP in governing porcine skeletal muscle development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-4138
pubmed:author
pubmed:copyrightInfo
Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-61
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Multiple alternative splicing and differential expression of actinin-associated LIM protein (ALP) during porcine skeletal muscle development in vitro and in vivo.
pubmed:affiliation
Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, College of Animal Science, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't