| pubmed-article:20374716 | pubmed:abstractText | Members of the R7 subfamily of regulator of G protein signaling (RGS) proteins (RGS6, 7, 9, and 11) exist as heterodimers with the G protein beta subunit G?5. These protein complexes are only found in neurons and are defined by the presence of three domains: DEP/DHEX, G?5/GGL, and RGS. This article summarizes published work in the following areas: (1) the functional significance of structural organization of G?5-R7 complexes, (2) regional distribution of G?5-R7 in the nervous system and regulation of R7 family expression, (3) subcellular localization of G?5-R7 complexes, and (4) novel binding partners of G?5-R7 proteins. The review points out some contradictions between observations made by different research groups and highlights the importance of using alternative experimental approaches to obtain conclusive information about G?5-R7 function in vivo. | lld:pubmed |
