Linked Life Data

20374716

Source:http://linkedlifedata.com/resource/pubmed/id/20374716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-4-8
pubmed:abstractText
Members of the R7 subfamily of regulator of G protein signaling (RGS) proteins (RGS6, 7, 9, and 11) exist as heterodimers with the G protein beta subunit G?5. These protein complexes are only found in neurons and are defined by the presence of three domains: DEP/DHEX, G?5/GGL, and RGS. This article summarizes published work in the following areas: (1) the functional significance of structural organization of G?5-R7 complexes, (2) regional distribution of G?5-R7 in the nervous system and regulation of R7 family expression, (3) subcellular localization of G?5-R7 complexes, and (4) novel binding partners of G?5-R7 proteins. The review points out some contradictions between observations made by different research groups and highlights the importance of using alternative experimental approaches to obtain conclusive information about G?5-R7 function in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1878-0814
pubmed:author
pubmed:copyrightInfo
Copyright © 2009 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-203
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Structure, function, and localization of G?5-RGS complexes.
pubmed:affiliation
Department of Molecular and Cellular Pharmacology and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural