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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2010-7-23
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pubmed:abstractText |
BO2C11 is a human monoclonal factor (F) VIII inhibitor. When bound to the C2 domain of FVIII, the Fab fragment of BO2C11 (Fab(BO2C11)) buries a surface of C2 that contains residues participating in a binding site for von Willebrand factor (VWF). BO2C11 has thus been proposed to neutralize FVIII by steric hindrance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1538-7836
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pubmed:author |
pubmed-author:AndreSS,
pubmed-author:AtanasovB PBP,
pubmed-author:DimitrovJ DJD,
pubmed-author:JacqueminMM,
pubmed-author:KaveriS VSV,
pubmed-author:Lacroix-DesmazesSS,
pubmed-author:MeslierYY,
pubmed-author:PlanchaisCC,
pubmed-author:PlantierJ-LJL,
pubmed-author:RoumeninaL TLT,
pubmed-author:SaboulardDD,
pubmed-author:Saint-RemyJ-MJM
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1524-31
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pubmed:meshHeading |
pubmed-meshheading:20374449-Antibodies, Monoclonal,
pubmed-meshheading:20374449-Binding Sites,
pubmed-meshheading:20374449-Epitopes,
pubmed-meshheading:20374449-Factor VIII,
pubmed-meshheading:20374449-Hemophilia A,
pubmed-meshheading:20374449-Humans,
pubmed-meshheading:20374449-Models, Molecular,
pubmed-meshheading:20374449-Mutagenesis, Site-Directed,
pubmed-meshheading:20374449-Mutation, Missense,
pubmed-meshheading:20374449-Static Electricity,
pubmed-meshheading:20374449-von Willebrand Factor
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pubmed:year |
2010
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pubmed:articleTitle |
A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF-binding site distant from its epitope.
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pubmed:affiliation |
Centre de Recherche des Cordeliers, Université Pierre et Marie Curie - Paris6, UMR S 872, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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