Linked Life Data

20373031

Source:http://linkedlifedata.com/resource/pubmed/id/20373031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-21
pubmed:abstractText
To investigate whether there is any association between various APOE alleles and factor V Leiden (FVL) with lipid profiles and sickle cell disease (SCD) in Southern Iran. 65 SCD patients consisting of 35 sickle cell anemia homozygous (SS), 15 sickle cell heterozygous (AS) and 15 sickle cell/?Thalassemia (S/?thal) patients and 68 healthy individuals with normal hematological indices were studied. APOE and FVL polymorphisms were detected by PCR-RFLP and serum lipid level was measured enzymatically. The frequencies of FVL and APOE-?4 allele were significantly higher in SCD patients than in control (15.4 vs. 4.4 and 13.7% vs. 3.3%, respectively). The distributions of APOE ?3?3, ?2?3 and ?2?4 + ?3?4 alleles in SCD patients were significantly different from those in the control group. The SCD subjects particularly SS/S ?thal (SS + S/?thal) and SS patients have significantly lower frequency of APOE ?3?3 allele (P < 0.05) whereas SCD, SS patients and AS individuals have a significantly higher frequency of APOE ?4 allele (?2?4 + ?3?4; P = 0.003, P = 0.011 and P = 0.035, respectively) compared to the control group. The LDL-C (P = 0.006) and total cholesterol (P < 0.001) levels in SCD subjects were found to be significantly lower than those in the control group. In addition, the presence of non-APOE ?4 allele (?2?3 + ?3?3) resulted in a significant decrease in the level of LDL-C and total cholesterol in SCD subjects in general and in SS and SS/S ?thal patients in particular compared to controls. Furthermore, the presence of APOE ?4 allele (?2?4 + ?3?4) was found to be associated with the risk of sickle cell anemia [OR = 4.1, P = 0.04]. The presence of either FVL mutation (OR = 4.6; CI: 0.91-24, P = 0.07) or APOE-?4 allele (OR = 4.07; CI: 1.01-16.4, P = 0.048) is associated with the risk of sickle cell disease in Southern Iran. This data suggest that the activation of coagulation system enhances thrombus generation and decreases antioxidant activity in SCD patients from Southern Iran.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1573-4978
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
703-10
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Association between apolipoprotein ?4 allele, factor V Leiden, and plasma lipid and lipoprotein levels with sickle cell disease in Southern Iran.
pubmed:affiliation
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't