Source:http://linkedlifedata.com/resource/pubmed/id/20370456
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-4-7
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| pubmed:abstractText |
Patients with pre-transplantation high levels of panel reactive antibody (PRA) have an increased risk of graft failure, and renal transplantation in sensitized patients remains a highly significant challenge worldwide. The influence of anti-human leukocyte antigen (HLA) antibodies on the development of rejection episodes depends on patient-specific clinical factors and differs from patient to patient. The HLA typing of the recipient might influence the development of anti-HLA antibodies. Some HLA antigens appear to be more immunogenic than others. The aim of this study is to demonstrate the distribution of HLA phenotypes in PRA-positive and PRA-negative end-stage renal disease (ESRD) patients on the basis of having sensitizing events or not. Our study included 642 (mean age: 41.54; female/male: 310/332) ESRD patients preparing for the first transplantation and who are on the cadaveric kidney transplantation waiting list of Istanbul Medical Faculty in 2008-2009. Class I HLA-A,B typing was performed by complement-dependent cytotoxicity (CDC) method, whereas class II HLA-DRB1 typing was performed by low-resolution polymerase chain reaction (PCR)-sequence-specific primer (SSP). All serum samples were screened for the presence of IgG type of anti-HLA class I- and II-specific antibodies by enzyme-linked-immunosorbent assay (ELISA). PRA-negative group consisted of 558 (86.9%) and PRA-positive group included 84 (13.1%) patients. We have found statistically significant frequency of HLA-A3 (p=0.018), HLA-A66 (p=0.04), and HLA-B18 (p=0.006) antigens in PRA-positive patients and DRB1*07 (p=0.02) having the highest frequency in patients with sensitizing event history but no anti-HLA development suggesting that DRB1*07 might be associated with low risk of anti-HLA antibody formation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1525-6049
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| pubmed:author |
pubmed-author:AydinAli EminAE,
pubmed-author:Bakkalo?luHüseyinH,
pubmed-author:Cali?kanYa?ar KeremYK,
pubmed-author:CarinMahmut NezihMN,
pubmed-author:EldegezUlugU,
pubmed-author:KarahanGonca EmelGE,
pubmed-author:KekikCigdemC,
pubmed-author:OguzFatma SavranFS,
pubmed-author:OnalAyse EmelAE,
pubmed-author:SeverMehmet SMS,
pubmed-author:TurkmenAydinA,
pubmed-author:YaziciHalilH
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
32
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
380-3
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| pubmed:meshHeading |
pubmed-meshheading:20370456-Adult,
pubmed-meshheading:20370456-Female,
pubmed-meshheading:20370456-HLA Antigens,
pubmed-meshheading:20370456-Histocompatibility,
pubmed-meshheading:20370456-Humans,
pubmed-meshheading:20370456-Isoantibodies,
pubmed-meshheading:20370456-Kidney Failure, Chronic,
pubmed-meshheading:20370456-Kidney Transplantation,
pubmed-meshheading:20370456-Male,
pubmed-meshheading:20370456-Phenotype
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Association of HLA phenotypes of end-stage renal disease patients preparing for first transplantation with anti-HLA antibody status.
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| pubmed:affiliation |
Department of Medical Biology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. gonca.karahan@gmail.com
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| pubmed:publicationType |
Journal Article
|