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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-7-2
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pubmed:abstractText |
Gastrin releasing peptide (GRP) has recently been shown to increase glucose-induced insulin secretion in vivo. Being present in pancreatic tissue, the 27-amino acid peptide could play a role in the control of the glucose-induced insulin secretion of islets of Langerhans. In the presence of a stimulatory glucose concentration, GRP augmented insulin secretion of isolated islets in batch incubations. The peptide did not affect 56Rb+ efflux in the presence of 3 or 5.6 mM glucose but reduced the increase of 86Rb+ efflux evoked by the calcium ionophore A23187. 45Ca2+ uptake and intracellular recorded electrical activity induced by glucose were amplified by GRP. It is suggested that GRP plays a role in the regulation of glucose-induced insulin secretion by increasing the uptake of Ca2+ directly or by inhibition of the Ca(2+)-dependent K+ channel activity and reduced repolarization of the cell.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3247-52
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2036987-Animals,
pubmed-meshheading:2036987-Calcium,
pubmed-meshheading:2036987-Calcium Radioisotopes,
pubmed-meshheading:2036987-Electrophysiology,
pubmed-meshheading:2036987-Gastrin-Releasing Peptide,
pubmed-meshheading:2036987-Gastrointestinal Hormones,
pubmed-meshheading:2036987-Glucose,
pubmed-meshheading:2036987-Insulin,
pubmed-meshheading:2036987-Islets of Langerhans,
pubmed-meshheading:2036987-Mice,
pubmed-meshheading:2036987-Mice, Inbred Strains,
pubmed-meshheading:2036987-Peptides,
pubmed-meshheading:2036987-Rubidium
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pubmed:year |
1991
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pubmed:articleTitle |
Gastrin releasing peptide augments glucose mediated 45Ca2+ uptake, electrical activity, and insulin secretion of mouse pancreatic islets.
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pubmed:affiliation |
Department of Pharmacology, Eberhard-Karls Universität Tübingen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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