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rdf:type |
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lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0003451,
umls-concept:C0025260,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0243067,
umls-concept:C0334094,
umls-concept:C0442886,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
9
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pubmed:dateCreated |
2010-4-22
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pubmed:abstractText |
Although previous studies have demonstrated delayed viral clearance and blunted effector T cell responses in aged mice during infection, memory CD8 T cells and especially secondary responses have received less attention. In this study, we show that modest differences in the number of memory CD8 T cells formed in aged versus young animals were associated with altered memory CD8 T cell differentiation. Aged immune mice had increased morbidity and mortality upon secondary viral challenge, suggesting changes in T cell immunity. Indeed, virus-specific memory CD8 T cells from aged mice showed substantially reduced proliferative expansion upon secondary infection using multiple challenge models. In addition, this defect in recall capacity of aged memory CD8 T cells was cell-intrinsic and persisted upon adoptive transfer into young mice. Thus, the poor proliferative potential of memory T cells and altered memory CD8 T cell differentiation could underlie age-related defects in antiviral immunity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
184
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5151-9
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pubmed:meshHeading |
pubmed-meshheading:20368274-Adoptive Transfer,
pubmed-meshheading:20368274-Aging,
pubmed-meshheading:20368274-Animals,
pubmed-meshheading:20368274-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20368274-Cell Differentiation,
pubmed-meshheading:20368274-Cell Line,
pubmed-meshheading:20368274-Cell Proliferation,
pubmed-meshheading:20368274-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:20368274-Dogs,
pubmed-meshheading:20368274-Epitopes, T-Lymphocyte,
pubmed-meshheading:20368274-Genetic Predisposition to Disease,
pubmed-meshheading:20368274-Immunodominant Epitopes,
pubmed-meshheading:20368274-Immunologic Memory,
pubmed-meshheading:20368274-Lymphocytic Choriomeningitis,
pubmed-meshheading:20368274-Lymphocytic choriomeningitis virus,
pubmed-meshheading:20368274-Mice,
pubmed-meshheading:20368274-Mice, Inbred C57BL,
pubmed-meshheading:20368274-Orthomyxoviridae,
pubmed-meshheading:20368274-Orthomyxoviridae Infections,
pubmed-meshheading:20368274-T-Lymphocyte Subsets,
pubmed-meshheading:20368274-Vaccinia virus
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pubmed:year |
2010
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pubmed:articleTitle |
Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection.
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pubmed:affiliation |
Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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