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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-5
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pubmed:abstractText |
Human pluripotent stem cells offer promise for use in cell-based therapies for brain injury and diseases. However, their cellular behavior is poorly understood. Here we show that the expression of the brain-specific microRNA-9 (miR-9) is turned on in human neural progenitor cells (hNPCs) derived from human embryonic stem cells. Loss of miR-9 suppressed proliferation but promoted migration of hNPCs cultured in vitro. hNPCs without miR-9 activity also showed enhanced migration when transplanted into mouse embryonic brains or adult brains of a mouse model of stroke. These effects were not due to precocious differentiation of hNPCs. One of the key targets directly regulated by miR-9 encodes stathmin, which increases microtubule instability and whose expression in hNPCs correlates inversely with that of miR-9. Partial inhibition of stathmin activity suppressed the effects of miR-9 loss on proliferation and migration of human or embryonic rat neural progenitors. These results identify miR-9 as a novel regulator that coordinates the proliferation and migration of hNPCs.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-10321251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-11731781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-11779458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-12007417,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-18667155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-18676805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-18694566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-18806776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-18842901,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-19167326,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-20362531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20362537-8598048
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1875-9777
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-35
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20362537-Humans,
pubmed-meshheading:20362537-Animals,
pubmed-meshheading:20362537-Mice,
pubmed-meshheading:20362537-Rats,
pubmed-meshheading:20362537-Neurons,
pubmed-meshheading:20362537-Cell Differentiation,
pubmed-meshheading:20362537-RNA, Messenger,
pubmed-meshheading:20362537-Cell Movement,
pubmed-meshheading:20362537-Cell Proliferation,
pubmed-meshheading:20362537-Gene Expression Regulation, Developmental,
pubmed-meshheading:20362537-Stathmin,
pubmed-meshheading:20362537-Embryonic Stem Cells
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