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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-2
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pubmed:abstractText |
Diffusion tensor imaging (DTI) recently identified structural abnormalities of corticomotoneurons in asymptomatic copper/zinc superoxide-dismutase-1 (SOD-1) gene mutation carriers. The potential existence of longstanding corticomotoneuronal dysfunction would clearly have consequences for the medical management of asymptomatic SOD-1 mutation carriers. To clarify this unexpected finding, DTI techniques were combined with threshold tracking transcranial magnetic stimulation (TMS) to assess the anatomical and functional integrity of corticomotoneurons in asymptomatic SOD-1 mutation carriers.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1872-8952
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 International Federation of Clinical Neurophysiology. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1781-5
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pubmed:meshHeading |
pubmed-meshheading:20362497-Action Potentials,
pubmed-meshheading:20362497-Adult,
pubmed-meshheading:20362497-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:20362497-Brain Mapping,
pubmed-meshheading:20362497-Cerebral Cortex,
pubmed-meshheading:20362497-Diffusion Tensor Imaging,
pubmed-meshheading:20362497-Electric Stimulation,
pubmed-meshheading:20362497-Female,
pubmed-meshheading:20362497-Humans,
pubmed-meshheading:20362497-Male,
pubmed-meshheading:20362497-Middle Aged,
pubmed-meshheading:20362497-Motor Neurons,
pubmed-meshheading:20362497-Mutation,
pubmed-meshheading:20362497-Neurologic Examination,
pubmed-meshheading:20362497-Peripheral Nerves,
pubmed-meshheading:20362497-Pyramidal Tracts,
pubmed-meshheading:20362497-Reaction Time,
pubmed-meshheading:20362497-Superoxide Dismutase
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pubmed:year |
2010
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pubmed:articleTitle |
Corticomotoneuronal function in asymptomatic SOD-1 mutation carriers.
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pubmed:affiliation |
Department of Neurology, Westmead Hospital, Western Clinical School, University of Sydney, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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