Linked Life Data

20362335

Source:http://linkedlifedata.com/resource/pubmed/id/20362335

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-8-2
pubmed:abstractText
Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1873-5835
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1242-5
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?
pubmed:affiliation
Laboratori de Citogenètica Molecular. Servei de Patologia, Parc Salut Mar. GRETNHE, IMIM-Hospital del Mar, Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't