Linked Life Data

20361248

Source:http://linkedlifedata.com/resource/pubmed/id/20361248

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-6-17
pubmed:abstractText
Pericentromeric repeats have been claimed to mediate centric fusions through heterologous recombination of arrays of tandemly repeated and highly homogenized motifs. However, mammalian case studies are essentially restricted to pathologic fusions in human, or to the house mouse Roberstonian (Rb) races. We here provide an example in a wild gerbil rodent, Gerbillus nigeriae, which displays an extensive Rb polymorphism, with 2n ranging between 2n = 60 and 74. The distribution of two closely related repeats, GERB1 and GERB2 that were previously isolated by Volobouev et al. (Chromosoma 104:252-259, 1995) in this African species, were investigated in the genomes of seven individuals with various diploid numbers. Our results clearly show that GERB1 and GERB2 are organized in a non-random manner, with GERB2 and GERB1 being clearly juxtacentromeric and centromeric, respectively. Finally, cloning and sequencing revealed that, unlike GERB2, GERB1 monomers display a more homogeneous organization at both the nucleotide and structural levels. Altogether, our results point toward a pivotal role of GERB1 repeats in the mediation of Rb fusions through heterologous recombination, with some evidence of subsequent loss of repeats after the Rb fusion during the course of evolution of metacentric elements. Moreover, the repeat pattern observed in G. nigeriae closely matches the organization and sequence structure of satellite DNAs described in human acrocentrics. Consequently, G. nigeriae appears as an additional model for the study of repeat evolution and its role in centric fusions and their consequences in mammals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1573-6849
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
473-86
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Robertsonian fusions, pericentromeric repeat organization and evolution: a case study within a highly polymorphic rodent species, Gerbillus nigeriae.
pubmed:affiliation
Institut de Recherche pour le Développement, Centre de Biologie et de Gestion des Populations (CBGP; UMR022 IRD-INRA-Montpellier SupAgro), Campus International de Baillarguet, CS30016, 34988, Montferrier-sur-Lez, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't